Assoc. Prof. Dr. Tan Jun Jie
Advanced Medical & Dental Institute
Email : jjtan@usm.my
Phone No. : +6(04) 653 (Ext) 2422
Objectives
Human induced pluripotent stem cells can generate pre-epicardial cells (PEC) that can stimulate heart cell growth, spatially organize them in the dish and improve their contractility.
The mechanism underlying the increased heart cell proliferation is partly by the retinoic acid / insulin- like growth factor mediated signaling. The collective effects from PEC on heart cells shows their important role especially in heart tissue engineering for regenerative purposes.
2021
Paper published in Nature Communication with Prof. Harald Ott from Harvard University, USA
Nature Communications
Ongoing Collaboration with Massachusetts General Hospital, Harvard Medical School, USA
The iPSC-derived preepicardial cells (green) spatially organized the heart cells (Magenta) to forma tube-like structure spontaneously in the dish
