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3rd Issue CurioUSMind

  • Our leading research scientist. Fostering a culture of excellence in science, technology, innovation and economy.

    Assoc. Prof. Ir. Dr. Leo Choe Peng

    Membrane science and technology for carbon capture, water recovery, and food purification.

    Assoc. Prof. Dr. Low Siew Chun

    Separation Technology, Membrane Synthesis, Wastewater Treatment, Biosensor

    Assoc. Prof. Dr. Sasidharan Sreenivasan

    Pharmacognosy

    Assoc. Prof. Ir. Dr. Cheah Chee Ban

    Construction Materials and Technology

    Prof. Dr. Chow Wen Shyang

    Polymer nanocomposites; biodegradable polymer; biopolymer; nanofiller; latex processing

    Prof. Dr. Chan Yean Yean

    Medical Molecular Microbiology, Biosensor, Diagnostics.

      INDUSTRIAL COLLABORATION

      Dr. Ooi Lu Ean

      School of Mechanical Engineering, Universiti Sains Malaysia

      IMPACTFUL RESEARCH

      Assoc. Prof. Dr. Raa Khimi Shuib

      Rubber That Heals Itself

      Assoc. Prof. Dr. Tan Jun Jie

      Stem Cells Could Help Repair Damaged Hearts

      • Top Research Scientist Malaysia : Assoc. Prof. Ir. Dr. Leo Choe Peng

        Assoc. Prof. Ir. Dr. Leo Choe Peng

        School of Chemical Engineering, Universiti Sains Malaysia

        Email: chcpleo@usm.my

        Phone No: (+6)04-599 6425


        Research Interests

        Membrane science and technology for carbon capture, water recovery, and food purification.

        My Research: Contribution & Expertise


        My research focuses on the mass transport through membranes and the interaction with a planar surface. The findings are vital for understanding the permeation theories and fouling mechanisms. I also study the enhanced extraction of functional food, such as microwave-assisted and subcritical extraction. Our team has developed carbon capture strategies, water recovery innovations, and food purification methods using the knowledge generated in our past studies. We have introduced carbonate as the carbon carrier, which enables us to store and utilize carbon dioxide. The carbonates are useful to kick-start the carbon circular economy involving fertilizer, paint and coating. My team also has incorporated IoT systemsin our water reuse projects. Data collection and system monitoring allow us to understand public acceptance and social behaviour in water reuse. Furthermore, sustainable food processing has been promoted by introducing enhanced extraction involving local products such as propolis and roselle seed.

        Carbon capture and conversion technology

        My View: Qualities of a Good Researcher


        A good researcher must have ethics, specifically using moral principles to govern their research decisions. Without ethics, actual findings will not be revealed. The useful knowledge will not be generated, and we are going nowhere.

        Outreach activities

      • Top Research Scientist Malaysia : Assoc. Prof. Dr. Low Siew Chun

        Assoc. Prof. Dr. Low Siew Chun

        School of Chemical Engineering, Universiti Sains Malaysia

        Email: chcpleo@usm.my

        Phone No: (+6)04-599 6425


        Research Interests

        Separation Technology, Membrane Synthesis, Wastewater Treatment, Biosensor



        My Research: Contribution & Expertise


        My research is focuses on air purification and water recovery using separation technologies that can be accomplished with minimal cost and energy. This approach transforms air pollution control and wastewater treatment from a liability technology to a desirable activity for industries. Currently, my research team focuses on extracting and recycling valuable materials from aquaculture effluent rather than purifying water. Aquaculture is expected to emerge as one of the major agricultural contributors to the national economy. However, the problem associated to this aquaculture industry is the huge volume of wastes. In this regard, I am focuses on exploiting membrane technology to extract nutrients from wastewater.

        We develop smart materials that alleviate membrane fouling problems, paving the way for more industrial uses of membrane separation technology. My team aims to achieve zero-waste discharge by recycling the purified water used in aquaculture activities and at the same time concentrating the wastewater feed as liquid fertilizer. The produced nutrient-rich liquid organic fertilizer will be used for plant growth to evaluate its effectiveness as nutrients for soil microbes and improving the soil structure. The research outputs are not only beneficial for the environment, but also have a favorable influence on the countries' social-economic well-being.

        My View: Qualities of a Good Researcher


        This is a question I often ask myself, and one which has been pondered over. I firmly believe that the study we conduct must be the kind of research that interests us and piques our curiosity. We can have the necessary intelligence. However, without curiosity and interest, we are not driven to go further to discover more insights. Second, I have to quote commitments. Research is a challenging job. The working hours can be long and deadlines can be tight. In terms of job execution, researchers must systematically plan their work. It may sound simple, but it took me a long time to understand how to prepare for the overall scope of research activities, so that I could re-validate my work within the allotted period. The last is the transmission of information. We may be talking to different audiences. To ensure that people can understand our results and what the results mean to them, excellent written and verbal communication is necessary.

      • Top Research Scientist Malaysia : Assoc. Prof. Dr. Sasidharan Sreenivasan

        Assoc. Prof. Dr. Sasidharan Sreenivasan

        Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia

        Email:  srisasidharan@usm.my

        Phone No: (+6)012-532 3462


        Research Interests

        Pharmacognosy

        My Research: Contribution & Expertise


        Fundamentally, I'm a Pharmaceutical biologist and pharmacognosist. I have vast research experience in transdisciplinary aspects of medicinal plant research, with the principal aim of highlighting the importance of medicinal plants in drug discovery. In recent years, herbal remedies have been considered dietary supplements for disease prevention and alternative/ complementary medicine. The WHO estimates that 80% of the world's population relies on traditional herbal medicine for primary health care. While thousands of plants have been documented in traditional medicine, less research has examined these wild resources; how they are integrated into modern medicine. My scientific research on medicinal plants, based on modern methods, significantly contributed to the generation of scientific data, leading to the merging of this knowledge into modern medicine.

        My View: Qualities of a Good Researcher


        A good researcher must have I believe an excellent researcher's three most crucial attributes are imagination, creativity and innovation. In science, if the outcome of the research activities creates new knowledge, imagination offers the research questions to be explored. Moreover, imagination also helps excellent scientists leapfrogged ahead of their contemporaries to the next level of science. Hence, as Einstein told an interviewer in 1929, imagination is more important than knowledge in science. Besides that, a good researcher should also be creative in their research journey to achieve the research goal. In addition, innovation in scientific research is the key to unlocking societal benefits, specifically in industry. Despite everything, the innovative approach is behind scientists' success in discovering and developing new, world- changing technologies.

      • Top Research Scientist Malaysia : Assoc. Prof. Ir. Dr. Cheah Chee Ban

        Assoc. Prof. Ir. Dr. Cheah Chee Ban

        School of Housing, Building and Planning, Universiti Sains Malaysia

        Email:  cheahcheeban@usm.my

        Phone No:
        (+6)04-653 2827 | (+6)016-484 6502


        Research Interests

        Construction Materials and Technology

        My Research: Contribution & Expertise


        To overcome the severe environmental degradation associated with natural resources mining for concrete production, Assoc. Prof. Ir. Dr Cheah Chee an strived to create novel reduced carbon footprint cement, alternative sand and stone for the construction industry. These alternative materials are produced from industrial by-products, solving the solid waste disposal problems through recycling them into functional construction material. As a result, he invented three national and one international patent granted and four national patents filed on green concrete, which received several national and international invention awards. Furthermore, integrating the inventions with the industrialized building system(IBS), he designed and built the first full-scale green concrete detached house in Malaysia for technology demonstration, research, development and education. Currently, he leads national research supported by MOSTI to develop new processes and innovative material design for large volume reuse of coal combustion by-products to manufacture concrete. Moreover, he initiated a collaboration with one of the country's top five concrete producers to create tangible value for businesses and society based on his inventions. Through the industry linkage, Dr Cheah has led the technology transfer to produce sustainable concrete used nationwide in structure and infrastructure construction to reduce the material and environmental costs of the construction industry.

         

        My View: Qualities of a Good Researcher


        I believe an excellent research scientist has a specific area of research focus and specialization. With that, the researcher can exert a consistent effort to develop new knowledge in the research focus area. Such effort contributes to developing the body of knowledge in the field. In essence, a good researcher focuses on three key results mainly to create new knowledge, share new knowledge locally and globally and translate the scientific knowledge developed to the community, businesses and industry. The translation of knowledge is an important process to create a tangible impact of the research output to benefit society and businesses towards developing the country into a high-tech nation. Besides high-quality research, an academic researcher's role is also oriented toward developing new talent for nation-building. In the context of the university, the talents are research students such as masters and PhD students who undertake their apprenticeship to learn crucial research skills that will benefit them in their long-term career and professional development. Therefore, the role of an academic researcher is, in essence, "Transforming Higher Education for a Sustainable Tomorrow".

      • Top Research Scientist Malaysia : Prof. Dr. Chow Wen Shyang

        Prof. Dr. Chow Wen Shyang

        School of Materials & Mineral Resources Engineering, Universiti Sains Malaysia

        Email: shyang@usm.my

        Phone No: (+6)04-599 6160


        Research Interests

        Polymer nanocomposites; biodegradable polymer; biopolymer; nanofiller; latex processing

        My Research: Contribution & Expertise


        I am an established researcher who is passionate about the development of sustainable and environmentally friendly polymer nanocomposites. From 2005 to 2022, I have published a total of 110 international journals, permeation theories and fouling journals, and 11 book chapters. My expertise is in the processing and characterization of biodegradable polymers, biopolymers and polymer nanocomposites. Most of my research focuses on the sustainability, environmentally friendly and recyclability of polymers, which is in line with the Circular Economy. Well-structured human resources development is essential to catalysing the socio-economic growth of Malaysia.

        A total of eight PhD and fifteen MSc postgraduate students have graduated under my supervision. The graduated postgraduate students are all well trained, which can be justified by their high-quality theses and international journal publications(approximately 3 publications/postgraduate) and their job market competitiveness (100% graduate employability for the 23 graduated students). Bionanocomposites can help to improve sustainability for the environment and create potential industrialization opportunities. The latest contribution of my research is working with industry to develop a sustainable recirculating aquaculture filtration system (containing nanocomposite foam) to solve the water quality problems of fish farms. Overall, the scientific findings from my research work can have a great impact on the advancement of knowledge in the polymer industry.

        My View: Qualities of a Good Researcher


        In my personal view, to be a good researcher, we need "STREAM", not only the continuous "flow" (continuous contribution), but the empowerment of the elements in the "STREAM".

        S - Sharing
        T - Transform
        R - Relearn
        E - Enthusiastic
        A - Action
        M - Management

        We need to share our findings from the research with the scientific community as well as other stakeholders. We should try our best to transform our knowledge and solve some of the problems (e.g., environmental pollution). Often, we need to learn and relearn about the research that we are working on. We can think out-of-the-box but make it always relevant. We should be enthusiastic about the research work. Enjoy your research! Please remember to take action on what you are thinking. Walk the talk! Last but not least, manage your time well so that you can have good quality "research-time", "familytime" and "me-time".

      • Top Research Scientist Malaysia : Prof. Dr. Chan Yean Yean

        Prof. Dr. Chan Yean Yean

        Department of Medical Microbiology & Parasitology, School of Medical Sciences, Universiti Sains Malaysia

        Email: yychan@usm.my

        Phone No: (+6)09-767 6258


        Research Interests

        Medical Molecular Microbiology, Biosensor, Diagnostics.

        My Research: Contribution & Expertise


        My research has contributed to progress in Life Sciences and resultant innovations have improved the quality of human life by tackling the bottleneck in current diagnostic testing platforms. Working in the field of diagnostics, my research has contributed to improving management strategies for diagnostics and surveillance of various infectious and genetic diseases, enabling rapid, accurate, sensitive, inexpensive, and point-of-care diagnosis. The multi disciplinary efforts in the development of assays provide user portable multi-sensor detection technologies that are able to give quick preventive action and early diagnosis to ensure the quality of life now and in the future. I have filed various proprietary technologies, specializing in providing affordable point-of-care tests, ambient temperature-stable end-point PCR, multiplex real-time PCR and biosensor tests. Besides working in the university environment, I am involved in licensing and am a consultant to industrial partners to help generate income for the university and the country through the commercialization of my research products.

        My View: Qualities of a Good Researcher


        The criteria to be a "Good researcher" is having a curious mind and attitude. All the issue surrounding us required idea to solve the problems. Thus, through the well plan works, proof by scientific data and reproducible results, all issue can be solved in the systematic ways. A good researcher enjoys exploring new finding to the problem and timely literature review for latest technologies. The enthusiasm in research work will not be easily affected by the negative feedback, but is an energy to move further with different approach and always with alternative possibilities. In whatever future undertaking that they put their efforts into, they will prove to be an excellent achiever.

      • Industrial Collaboration : Dr. Ooi Lu Ean

        Dr. Ooi Lu Ean

        School of Mechanical Engineering, Universiti Sains Malaysia

        Email: ooiluean@usm.my

        Phone No:(+6)04-599 6315

        Dr. Ooi displays micro-perforated panel samples developed from the Dyson-USM Crest research grant project

        What is the proudest moment?

        When Dyson first approached me about collaboration, I was still very new to the lecturer profession. I want to establish healthy, long lasting relationships with the people I work within the industry. As a researcher at a university, one of my goals is to produce results that will be useful to society or industry, particularly if those results would hasten economic growth or result in an increase in graduate employability for students. I want to express my appreciation for the fact that the contact between the USM team and the Dyson team has been positive from the very beginning of the partnership. We broadened the scope of our connection to encompass a variety of exchanges. The team rom TheVibrationLab at USM put together a specialised training for the Dyson team to demonstrate various measurement techniques and facilitate information sharing. The members of the Dyson team also participated in the International Conference on Vibration, Sound, and System Dynamics, which was hosted by TheVibrationLab.

        Dr. Ooi displays micro-perforated panel samples developed from the Dyson-USM Crest research grant project

        The moment that made me the most proud was when I saw the high degree of interest from the industry partner after witnessing the efficiency of the strategy that I proposed. Knowing that the efforts are being recognised by a global corporation is both satisfying and reassuring. It is especially encouraging that it occurred at the beginning of my research journey because it indicates that I am on the right track. I am able to demonstrate that the idea that is being proposed has commercial value and is capable of resolving the actual challenges that are being faced by the industry in terms of design and development.

        This was done to demonstrate their support and to further our connections. Postgraduate students who participated in this project were provided with the opportunity to complete an industry attachment with Dyson, which comprised both on-site and off-site employment. These are encouraging indicators for the industry collaboration projectsince they will result in improved bonding and further knowledge exchange.

        Configuration for measuring the vacuum cleaner in the semi-anechoic chamber


        What is the biggest challenge you faced to ensure the success of the project?

        The establishment of trust between two individuals is essential to the development of any kind of relationship or personal connection. Establishing trust is not an easy process under any circumstances, but it becomes an especially challenging when working on a project that requires cooperation from various organizations.

        Due to the possibility that the project would involve confidential information, trust is absolutely a necessary for the success of the partnership. By conducting myself in a professional manner, I can earn the trust of my industry partners and keep our long-term partnerships strong.

        Details ef the 3D-printed micro perferated panel samples

        What is the future direction of the project?

        Establishing a long-term partnership with an industry partner, in my opinion, is essential for advancing research and benefiting students. Even while the experience obtained from each project might be unique, it can undoubtedly aid in developing a two way transfer of knowledge, that are advantageous to both the academic community and industry.

        My work with Dyson involved analysing the viability of an option for a sound absorber that is known as a micro perforated panel. We collaborate very closelyto ensure that the outcome of the project is of high quality and that it is a successful endeavour. I am confident that the industry research collaboration project will increase the number of opportunities available to both students and researchers. My ability to identify solutions for industry problems has been improved by the experiences I have gained through industry research projects. I can apply the lessons that I have learned as well as the experiences that I have gained to my class.

        As a member of the university staff, it is my responsibility to strike a balance between the benefits of university and industry partner. Depending on the nature of the collaboration, the deliverables could be a research article or a patent. When discussing any kind of research collaboration, patent ownership is guaranteed to be the most interesting topic. We are glad to have reached a mutually beneficial agreement that benefits both USM and Dyson. We are grateful for the trust that has been earned all across the duration of the project, as it will assist in ensuring that the project is completed smoothly.

        Staffs from USM team, Dyson team and Crest team in the International Conference on Vibration, Sound and System Dynamics 2019 organised by TheVibrationLab, USM

        Dyson staffs attend the workshop organised by TheVibrationLab, USM

      • Impactful Research : Rubber That Heals Itself

        Assoc. Prof. Dr. Raa Khimi Shuib

        School of Materials & Mineral Reseurces Engineering, Universiti Sains Malaysia

        Email:  raakhimi@usm.my

        Phone No: (+6)04-599 6122


        Innovative Research Advances

        The natural healing chemistry within rubber trees has inspired the development of self- healing rubber that could prevent catastrophic failures of rubber components.

        The USM team took inspiration from the natural processes in rubber trees to develop their new self-healing rubber. Natural rubber tree contains small bodies called lutiods that burst open when the tree is damaged. The lutiods release a repair protein called hevein, which is stimulated by calcium ions to form molecular crosslinks that seal the wound and prevent more latex from escaping. In a related way, the USM system uses zinc ions to form reversible ionic molecular networks based on sulfur- containing chemicals called thiolate ions. The healing can occur at normal room temperature with no external intervention required.


         

        Rubber that will naturally repair itself after damage has been developed by researchers at the School of Materials and Mineral Resources Engineering at the Universiti Sains Malaysia.

        In addition to its most obvious everyday uses, such as in vehicle tyres, rubber also serves in a vast range of engineering and domestic applications and failure can have damaging or even catastrophic consequences. Components such as bearings, gaskets, hoses and cables, for example, can play a critical role in everything from vehicles, aircraft and spacecraft, to industrial machinery and domestic appliances.

        Normally, any critical rubber parts need to be regularly inspected by human eye or automatic monitoring equipment to identify degradation and damage and arrange replacement or repair before failure might occur.

        "Our new self-healing rubber contributes to worldwide efforts to avoid these difficulties," says Dr Raa Khimi, of the USM team. He points out that the problems with conventional rubber lead to vast quantities of it being scrapped every year. Much of this waste cannot be readily recycled due to the strong chemically cross- linked networks in vulcanized rubber.

        "We need more sustainable rubber products for environmental, economic, reliability and safety reasons," Dr Raa Khimi adds, "and self-healing rubber is one of the most appealing approaches."

        Tests that modelled the damage sustained during normal use revealed that incorporating the healing chemistry could allow 100% immediate recovery of the original mechanical properties of rubber. The chemistry that performs the healing is reversible and repeatable, in a way that allows continuing mechanical damage to be repaired as it occurs. Moreover, the self- healing process increases the overall lifespan of the rubber by 60 percent.

        The research was published in the journal Polymer Testing and the team are now working to further characterise and refine the performance of their innovative material.

        "We believe that our novel approach could be widely applied and may greatly increase interest in the use of rubber products in automotive, aerospace, engineering and electronics applications," Dr Raa Khimi concludes.

      • Impactful Research : Stem Cells Could Help Repair Damaged Hearts

        Assoc. Prof. Dr. Tan Jun Jie

        Advanced Medical and Dental Institute (IPPT), Universiti Sains Malaysia

        Email: jjtan@usm.my

        Phone No: (+6)04-562 2422

        Understanding how different types of cells interact in embryos to build a human heart could lead to better grafts for healing mature hearts.


        New stem cell research at Universiti Sains Malaysia's Advanced Medical and Dental Institute could lead to more sophisticated and repairing damaged hearts. Their findings were published in the journal Nature Communications.

        Mature human cells collected from blood or skin can be programmed to re-enter an embryonic state and eventually go on to develop into different types of mature cells.

        The USM scientists used a cocktail of natural cell-stimulating proteins to convert these 'human induced pluripotent stem cells' (hiPSC cells) into a premature form of epicardial cells: essential precursors of several essential cell types needed to build a developing heart. The team investigated how these pre-epicardial cells can direct the essential activities of the heart muscle cells (known as cardiomyocytes) that power heart contraction.

        Mature cell and tissue grafts for repairing damaged hearts. Their findings were published in the journal Nature Communications. Mature human cells collected from blood or skin can be programmed to re-enter an embryonic state and eventually go on to develop into different types of mature cells.

        The USM scientists used a cocktail of natural cell-stimulating proteins to convert these 'human induced pluripotent stem cells' (hiPSC cells) into a premature form of epicardial cells: essential precursors of several essential cell types needed to build a developing heart. The team investigated how these pre-epicardial cells can direct the essential activities of the heart muscle cells (known as cardiomyocytes) that power heart contraction.

        "Cardiomyocytes derived from hiPSCs hold broad potential for treating heart conditions, and for promoting research to investigate heart disease, engineer heart tissues for therapeutic grafts and screen potential drugs targeting heart conditions," says USM Associate Professor Jun Jie Tan.


        Tan and his USM colleagues worked on the research with a team from the Center for Regenerative Medicine at Massachusetts General Hospital, Harvard Medical School in the USA. The Harvard researchers, led by Harald Ott, are exploring options for developing organ and tissue engineering methods as an alternative to organ transplantation. The researchers co-cultured their pre-epicardial cells with cardiomyocytes to explore how they interact, modelling what happens in a developing embryo. They found that the cardiomyocytes grouped together into dense aggregates with the help of the pre-epicardial cells, and formed a connected and regularly beating tissue mass. These changes occurred while the pre-epicardial cells became more mature and secreted a growth factor protein that could stimulate cardiomyocyte proliferation. So, with cultured cells in a dish, the team has recreated key steps towards a beating heart.

        Overall, this study suggests that pre-epicardial cells could be used to help produce viable, engineered cardiac tissues for use in therapeutic tissue grafts and in research. It also advances the basic understanding of how hearts develop in human embryos, which could assist developments in the diagnosis and treatment of a variety of heart conditions.

        "We believe our work could help create more sophisticated, mature and therefore more useful cardiac tissue grafts," Tan says.